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  1. DNA methylation is affected by age and environmental exposures. Abnormal DNA methylation is a sign of colorectal cancer. In a comparison between black and white individuals, the right colon seems to age quicker in black people. According to results from a biopsy study, this could explain the higher frequency of right-side colon cancer among African Americans. Read the original publication of this study here: [Racial Disparities in Epigenetic Aging of the Right vs. Left Colon] This colon cancer study aimed to make comparative studies of racial differences in site-specific colon
  2. The impact of medicinal and culinary herbs and botanicals has been studied extensively. The term might be new, but botanical biohacking has been used for centuries to optimize gut health. Gut health has a direct impact on our epigenome. Read on to learn more. RELATED: How The Environment You Grew Up In Can Have Long Term Effect On Genes In this article: Microbiomes Biohacking Epigenetics Use Botanical Biohacking to Support Your Epigenome Microbiomes Picture a bustling city filled with people during rush hour and imagine this
  3. Porcine epidemic diarrhea virus (PEDV), a highly contagious swine coronavirus, first emerged in America in 2013. The outbreak caused high death rates in the pork industry escalating from the US to Mexico and Canada. Although experts believe PEDV cannot be transmitted to humans, like other coronaviruses, they are noted for their capacity to suspend innate immune response, giving rise to an infection’s persistence and severity. Despite best efforts, no definite drug treatment has been developed, and therefore the disease remains challenging to control. Read the original publica
  4. Hereditary transthyretin (TTR) amyloidosis (hATTR) is a rare, life-threatening disorder caused by amyloidogenic coding mutations located in the TTR gene. To date, more than 130 amyloidogenic mutations have been identified in the coding regions of the TTR gene, which are the cause of the disorder. Previous data strongly support the role of non-coding regulatory variation on TTR gene expression as one of the mechanisms affecting the phenotypic manifestations observed in carriers of TTR amyloidogenic mutations. Epigenetic modifications are fundamental mechanisms in modulating a wid
  5. Human evolution is at work in the Andes mountains. People have evolved genetic adaptations to survive high altitude living. A recent study has highlighted chemical changes that control the activity of that DNA. Read on to learn more. RELATED: The Link Between Epigenetics And Social Factors New Studies on High Altitude Living Highlights Chemical Changes That Control the Activity of That DNA Cold temperatures, scarce oxygen, and intense ultraviolet radiation make the Andes a tough place to live. Not everyone can do it either. Indigenous people have lived
  6. Scientists believe that cellular senescence is a rudimentary driver of aging in organisms in a stable arrest state. Researchers Wang et al., in collaboration with the Institute of Zoology of the Chinese Academy of Sciences (CAS), Peking University, and Beijing Institute of Genomics of CAS, have teamed up to find new human senescence-promoting genes. Using a screening system known as CRISPR/Cas9, the team has shed new light on aging regulation. Read the original publication of this study here: A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
  7. A recent study looks at the effect of Bisphenol-A (BPA) on obesity, weight loss, and epigenetics. The findings could change the way we approach weight loss and epigenetics. RELATED: Obesogenic Diet Drives Epigenetic Predisposition To Metabolic Disorders In this article: Background Study Methods and Results Conclusion Study Uncovers Potential for Weight Loss and Epigenetics Background Obesity is on the rise, but despite attempts to find the underlying causes, the reasons for the epidemic are still unclear. However, there's a correlation between e
  8. A recent study published in Nature claims that scientists can restore eyesight to a youthful state. Read on to learn more. RELATED: Epigenetic Clock May Predict Brain Aging and Dementia In this article: Background Studies Findings Summary Points Can Science Really Restore Eyesight? Background Throughout our lifetime, DNA methylation and other epigenetic changes effectively switch genes on or off in specific tissues. As gene expression is altered with age, cells can lose their identity or stop working. The patterns of gene expression tha
  9. Aging and lifestyle factors increase susceptibility to SARS-CoV-2. A healthy lifestyle may also improve mitochondrial health. Therefore, lifestyle may be crucial in resisting the virus. RELATED: Epigenetic Modifications -- Can Scientists Turn Off SARS-CoV-2? In this article: Lifestyle Increase SARS-CoV-2 Risk Mitochondrial Health Exercise and Immune Function Therapeutic Strategy Lifestyle Increase SARS-CoV-2 Risk The risk of severe infection linked to SARS-CoV-2 increases with age and a few other underlying health conditions. As a result, up to
  10. A recent study found fertility linked to biological age. We take a closer look at the findings and possible implications. RELATED: The 6 Best Ways To Disturb Patterns of Methylation In this article: Background and Study Overview Study Findings: Fertility Linked to Biological Age Implications and Conclusion Background and Study Overview Between 9% and 24% of patients undergoing ovarian stimulation for in vitro fertilization (IVF) have an inadequate ovarian response (POR). It's a common clinical challenge, leaving both fertility experts and patien
  11. Advances in Alzheimer's disease have been a long time coming. After two decades without new medication, epigenetics is changing our approach, and some of the mysteries surrounding this disease are beginning to open up. We hope to soon gain new insights into ways to end the disease. RELATED: How To Optimize Brain Health And Longevity With Epigenetics In this article: A New Approach To Alzheimer's Disease Recent Findings Tau Protein and Epigenetics A New Approach To Alzheimer's Disease Two proteins in the brain called beta-amyloid plaques and tau tangl
  12. Researchers hope to shine a light on brain aging and dementia with a new epigenetic clock, a critical component in preventing, slowing, or even reversing traits related to aging. RELATED: Epigenetics And Aging: How Some People Are Able To Age Better In this article: Brain Aging and Dementia DNA Methylation and Brain Aging New Cortical Clock Brain Aging and Dementia Our brains age at different rates. Where chronological age is the number of years we have been alive, our biological age is how our cells seem. . These rates of aging often differ.
  13. Using a new algorithm, researchers reveal a previously undetected collection of cancer driver genes. As a result, our knowledge of epigenetic mechanisms in tumorigenesis and cancer prediction is improving. RELATED: Machine Learning and Clinical Epigenetics In this article: Cancer Driver Genes DORGE Algorithm How Cancer Prediction Is Improving Cancer Driver Genes Cancers stem from a build-up of genetic changes in the DNA of normal cells. These changes upset the balance between cell division and apoptosis (programmed cell death) and result in a n
  14. The US, Republic of Ireland, and Northern Ireland will join forces on a new project that looks at how psychological, behavioral, environmental, and social factors in childhood impact gene expression, aging, and health later in life. RELATED: Hallmarks of Aging In this article: Epigenetics and Social Factors Project Longitudinal Studies From Each Country Epigenetics and Social Factors Project Stressful events like violence, neglect, and hunger in childhood, may cause epigenome changes that last for decades. Therefore, researchers from the US, Norther
  15. The study identifies epigenetic changes that correlate strongly with observed age in rats. It also details physical performance independent of cell makeup and age. Moreover, it shows that interventions such as caloric restriction(CR) and cellular reprogramming impact mammalian aging. RELATED: 3 Things You Can Learn From An Epigenetic Blood DNA Test In this article: Rat Epigenetic Clock Study Background Rat Epigenetic Clock Study Findings Study Conclusion Rat Epigenetic Clock Study The study measured DNA Methylation (DNAm) using blood samples fr
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