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  2. DNA methylation is affected by age and environmental exposures. Abnormal DNA methylation is a sign of colorectal cancer. In a comparison between black and white individuals, the right colon seems to age quicker in black people. According to results from a biopsy study, this could explain the higher frequency of right-side colon cancer among African Americans. Read the original publication of this study here: [Racial Disparities in Epigenetic Aging of the Right vs. Left Colon] This colon cancer study aimed to make comparative studies of racial differences in site-specific colon
  3. The impact of medicinal and culinary herbs and botanicals has been studied extensively. The term might be new, but botanical biohacking has been used for centuries to optimize gut health. Gut health has a direct impact on our epigenome. Read on to learn more. RELATED: How The Environment You Grew Up In Can Have Long Term Effect On Genes In this article: Microbiomes Biohacking Epigenetics Use Botanical Biohacking to Support Your Epigenome Microbiomes Picture a bustling city filled with people during rush hour and imagine this
  4. Porcine epidemic diarrhea virus (PEDV), a highly contagious swine coronavirus, first emerged in America in 2013. The outbreak caused high death rates in the pork industry escalating from the US to Mexico and Canada. Although experts believe PEDV cannot be transmitted to humans, like other coronaviruses, they are noted for their capacity to suspend innate immune response, giving rise to an infection’s persistence and severity. Despite best efforts, no definite drug treatment has been developed, and therefore the disease remains challenging to control. Read the original publica
  5. Hereditary transthyretin (TTR) amyloidosis (hATTR) is a rare, life-threatening disorder caused by amyloidogenic coding mutations located in the TTR gene. To date, more than 130 amyloidogenic mutations have been identified in the coding regions of the TTR gene, which are the cause of the disorder. Previous data strongly support the role of non-coding regulatory variation on TTR gene expression as one of the mechanisms affecting the phenotypic manifestations observed in carriers of TTR amyloidogenic mutations. Epigenetic modifications are fundamental mechanisms in modulating a wid
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  7. Human evolution is at work in the Andes mountains. People have evolved genetic adaptations to survive high altitude living. A recent study has highlighted chemical changes that control the activity of that DNA. Read on to learn more. RELATED: The Link Between Epigenetics And Social Factors New Studies on High Altitude Living Highlights Chemical Changes That Control the Activity of That DNA Cold temperatures, scarce oxygen, and intense ultraviolet radiation make the Andes a tough place to live. Not everyone can do it either. Indigenous people have lived
  8. Scientists believe that cellular senescence is a rudimentary driver of aging in organisms in a stable arrest state. Researchers Wang et al., in collaboration with the Institute of Zoology of the Chinese Academy of Sciences (CAS), Peking University, and Beijing Institute of Genomics of CAS, have teamed up to find new human senescence-promoting genes. Using a screening system known as CRISPR/Cas9, the team has shed new light on aging regulation. Read the original publication of this study here: A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
  9. A recent study looks at the effect of Bisphenol-A (BPA) on obesity, weight loss, and epigenetics. The findings could change the way we approach weight loss and epigenetics. RELATED: Obesogenic Diet Drives Epigenetic Predisposition To Metabolic Disorders In this article: Background Study Methods and Results Conclusion Study Uncovers Potential for Weight Loss and Epigenetics Background Obesity is on the rise, but despite attempts to find the underlying causes, the reasons for the epidemic are still unclear. However, there's a correlation between e
  10. A recent study published in Nature claims that scientists can restore eyesight to a youthful state. Read on to learn more. RELATED: Epigenetic Clock May Predict Brain Aging and Dementia In this article: Background Studies Findings Summary Points Can Science Really Restore Eyesight? Background Throughout our lifetime, DNA methylation and other epigenetic changes effectively switch genes on or off in specific tissues. As gene expression is altered with age, cells can lose their identity or stop working. The patterns of gene expression tha
  11. Man, I knew it was bad, but HIV apparently sucks on levels I didn't even know existed. "Untreated HIV infection is linked with epigenetic changes that suggest rapid aging...epigenetic age exceeds their chronological age by 14 years... HIV speeds up at least this aging mechanism." I wonder how quickly folks with HIV develop that change in aging, once they catch it. Is the advanced aging methylation super fast? Or is it something you can head off if you catch it quickly enough? If your diagnosis and resulting treatment is super fast after you originally contract the virus, can you cut
  12. Aging and lifestyle factors increase susceptibility to SARS-CoV-2. A healthy lifestyle may also improve mitochondrial health. Therefore, lifestyle may be crucial in resisting the virus. RELATED: Epigenetic Modifications -- Can Scientists Turn Off SARS-CoV-2? In this article: Lifestyle Increase SARS-CoV-2 Risk Mitochondrial Health Exercise and Immune Function Therapeutic Strategy Lifestyle Increase SARS-CoV-2 Risk The risk of severe infection linked to SARS-CoV-2 increases with age and a few other underlying health conditions. As a result, up to
  13. A recent study found fertility linked to biological age. We take a closer look at the findings and possible implications. RELATED: The 6 Best Ways To Disturb Patterns of Methylation In this article: Background and Study Overview Study Findings: Fertility Linked to Biological Age Implications and Conclusion Background and Study Overview Between 9% and 24% of patients undergoing ovarian stimulation for in vitro fertilization (IVF) have an inadequate ovarian response (POR). It's a common clinical challenge, leaving both fertility experts and patien
  14. Advances in Alzheimer's disease have been a long time coming. After two decades without new medication, epigenetics is changing our approach, and some of the mysteries surrounding this disease are beginning to open up. We hope to soon gain new insights into ways to end the disease. RELATED: How To Optimize Brain Health And Longevity With Epigenetics In this article: A New Approach To Alzheimer's Disease Recent Findings Tau Protein and Epigenetics A New Approach To Alzheimer's Disease Two proteins in the brain called beta-amyloid plaques and tau tangl
  15. Researchers hope to shine a light on brain aging and dementia with a new epigenetic clock, a critical component in preventing, slowing, or even reversing traits related to aging. RELATED: Epigenetics And Aging: How Some People Are Able To Age Better In this article: Brain Aging and Dementia DNA Methylation and Brain Aging New Cortical Clock Brain Aging and Dementia Our brains age at different rates. Where chronological age is the number of years we have been alive, our biological age is how our cells seem. . These rates of aging often differ.
  16. Using a new algorithm, researchers reveal a previously undetected collection of cancer driver genes. As a result, our knowledge of epigenetic mechanisms in tumorigenesis and cancer prediction is improving. RELATED: Machine Learning and Clinical Epigenetics In this article: Cancer Driver Genes DORGE Algorithm How Cancer Prediction Is Improving Cancer Driver Genes Cancers stem from a build-up of genetic changes in the DNA of normal cells. These changes upset the balance between cell division and apoptosis (programmed cell death) and result in a n
  17. The US, Republic of Ireland, and Northern Ireland will join forces on a new project that looks at how psychological, behavioral, environmental, and social factors in childhood impact gene expression, aging, and health later in life. RELATED: Hallmarks of Aging In this article: Epigenetics and Social Factors Project Longitudinal Studies From Each Country Epigenetics and Social Factors Project Stressful events like violence, neglect, and hunger in childhood, may cause epigenome changes that last for decades. Therefore, researchers from the US, Norther
  18. The study identifies epigenetic changes that correlate strongly with observed age in rats. It also details physical performance independent of cell makeup and age. Moreover, it shows that interventions such as caloric restriction(CR) and cellular reprogramming impact mammalian aging. RELATED: 3 Things You Can Learn From An Epigenetic Blood DNA Test In this article: Rat Epigenetic Clock Study Background Rat Epigenetic Clock Study Findings Study Conclusion Rat Epigenetic Clock Study The study measured DNA Methylation (DNAm) using blood samples fr
  19. A new study from UCLA shows that antiretroviral therapy given to patients over two years was unable to restore age-appropriate epigenetic patterns. The results mean suggest that patients are experience rapid aging and are more likely to suffer from aging-related illnesses. RELATED: Epigenetic Marks: What They Are, and Why They Matter In this article: Epigenetics Antiretroviral Therapy Prior Research The Study Background Method Results Summary Points Antiretroviral Therapy and Epigenetics Epigenetics A person’s genet
  20. Researchers have discovered biomarkers of autism in the umbilical cord, which could aid physicians in making an early diagnosis of autism spectrum disorder (ASD), and thus create intervention strategies. RELATED: Study Shows The Older A Person Is When They Give Birth, The Older They May Live In this article: What Is Autism? What Are The Symptoms of Autism? Why Is Early Diagnosis Important? What Are The Treatments For ASD? Biomarkers of ASD in the Umbilical Cord Epigenetics Summary Points Biomarkers of Autism Found in Umbilical Co
  21. Kitov Pharma has recently announced new data that supports NT-219 as monotherapy for the treatment of advanced solid tumors. RELATED: What Is The Role Of Senescent Cells in Aging? In this article: What is NT-219? Clinical Trials Announcements From Kitov Summary Points Data Underpins Potential of NT-219 to Overcome Advanced Solid Tumors Kitov Pharma Ltd. (Kitov) is a clinical-stage drug developer using cutting-edge therapies to overcome drug resistance and tumor immune evasion. The company’s preliminary aim is to create long-lasting
  22. Too much methylation is a problem as it can cause various disease states and speed up the aging process. However, there are ways we can disturb methylation expression and optimize our health. RELATED: What Is The Role Of Senescent Cells in Aging? In this article: Methylation Expression and Aging 6 Ways to Disturb Methylation Expression Get Essential Nutrients Eat Foods Rich in Methylation Adaptogens Reduce Calorie Intake Limit Alcohol Consumption Get Regular Exercise Manage Stress Levels Methylation Expression and Aging It has been obs
  23. The global pandemic has changed almost every factor of people’s lives. From economic devastation to peoples' music taste, the world has been dramatically impacted by COVID-19 by altering our lives in many different ways. Believe it or not, COVID-19 has even had an impact on the body's largest organ- the virus is changing the skin's epigenetic regulation. RELATED: What Is The Role Of Senescent Cells in Aging? In this article: How the Pandemic Has Caused Physical Skin Changes The Epigenetic Regulation of Skin How the Epigenetic Regulation of Skin is Changing
  24. Epigenetics and anxiety have a scientifically-backed relationship. Increasing numbers of studies show that stress-related disorders, like anxiety, are contributed by abnormalities in epigenetic mechanisms of gene expression. RELATED: We Can Now Turn Back the Biological Clock: 5 Advantages of Epigenetics In this article: Anxiety Disorders (ADs) Scope Epigenetics and Anxiety Pathogenesis Implications of Epigenetic Drugs in Anxiety Disorders Trials of Epigenetics and Anxiety Drugs What We Know About Epigenetics and Anxiety Epigenetics and Anxiety: Patho
  25. One animal study shows a link between telomere length and metabolic aging. Read on to learn all about it. RELATED: How To Turn Back Your Biological Clock? Know Your Epigenetic Biomarkers In this article: What Are Telomeres? How Are They Linked to the Lifespan? Are there Ways to Lengthen Telomeres? What Happens When You Lengthen Telomeres in Mice? Telomere Length and Metabolic Aging: What You Need to Know What Are Telomeres? Telomeres are protein structures at the end of chromosomes. They serve to protect the ends of chromosomes in order to prev
  26. Research shows a link between telomere length and longevity. Read on to learn more about telomeres. RELATED: New Study Shows A Body’s Biological Age Can Be Reversed In this article: What Is a Telomere? Why Are Telomeres Important? How Are They Linked to Longevity and Aging? What Contributes to Telomere Shortening? Are There Other Telomere Interventions? What’s Next? Everything You Need to Know About Telomere and Longevity What Is a Telomere? Telomeres are structural components of DNA. You can find telomeres at the end of each DN
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